Tributoxy Ethyl Phosphate (TBEP)

Catalog NumberACM78513-2

CAS Number78-51-3

CategoryPhosphate Ester Flame Retardant

Synonyms	Tributoxy Ethyl Phosphate (TBEP)
Molecular Weight	398.48
Molecular Formula	C18H39PO7
Appearance	colorless transparent liquid
Application	As floor polishing agent and processing agent of water-based adhesive; as flame retardant and plasticizer of acrylonitrile type rubber, cellulose acetate, epoxy resin, ethyecellulose, polyvinyl acetate, thermoplastic and thermosetting polyurethane; as defoamer in coating, detergent and textiles. Moreover, the product is also used in nitrocellulose, ethyecellulose and acrylic plastic plasticizer.
Packaging	Net weight 200KG/galvanized iron drum or 1000KG/IB container barrel.
Refractive Index	nD25 1.4320 -1.4380
Specific Gravity	1.012-1.023

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Case Study

Neurobehavioral and Neuroinflammatory Effects of Tributoxy Ethyl Phosphate in Allergic Asthmatic Mice

Win-Shwe, Tin-Tin, et al. International Journal of Molecular Sciences 23.2 (2022): 655.

Tributoxy Ethyl Phosphate (TBEP) is an organophosphate flame retardant widely used in household products. This study evaluated its neurotoxicity in allergic asthmatic mouse models, focusing on memory function and neuroinflammatory responses.
Experimental Protocol: C3H/HeJSlc male mice (5-11 weeks old) were exposed to dietary TBEP at 0.02 (L), 0.2 (M), or 2 (H) μg/kg/day. Mice were intratracheally administered ovalbumin (OVA) every other week to induce allergic asthma. At 11 weeks old, novel object recognition tests were conducted, followed by hippocampus collection for molecular and immunohistochemical analyses.
Safety Assessment Results: High-dose TBEP (H) impaired object discrimination ability in mice with or without OVA. mRNA levels of NMDA receptor subunits (Nr1, Nr2b), pro-inflammatory markers (TNF-α, IL-1β), oxidative stress marker (HO-1), and glial markers (Iba1, GFAP) were significantly upregulated in TBEP-H groups. Immunohistochemistry revealed enhanced activation of microglia and mast cells in OVA+TBEP-H mice. Results indicate TBEP induces neuroinflammation and cognitive deficits via neuron-glia-mast cell crosstalk, highlighting its potential neurotoxic risks.

Photocatalytic Degradation of Tributoxy Ethyl Phosphate in Aqueous Environments

Konstas, Panagiotis-Spyridon, et al. International Journal of Environmental Analytical Chemistry 99.4 (2019): 297-309.

Tributoxy Ethyl Phosphate (TBEP) is a widely used organophosphate flame retardant and plasticizer that persists in water. This study evaluated its photocatalytic degradation using visible-light-responsive catalysts, addressing water contamination concerns.
Experimental Protocol: TBEP aqueous solutions (0.5-10 mg/L) were treated with catalysts including N-doped-SrTiO3, TiO2/V2O5, and N,F-doped-TiO2/V2O5. Suspensions with 200 mg/L catalyst were stirred in the dark for 30 min to reach adsorption equilibrium, then irradiated under simulated solar light (500 W/m²). Samples were filtered and analyzed via UPLC-LIT-Orbitrap-MS to identify transformation products.
Degradation Evaluation: Degradation followed first-order kinetics, with N-doped-SrTiO3 showing the highest efficiency (half-life = 9.8 min, k = 0.071 min-1). ·OH radicals were confirmed as key oxidants via scavenging experiments. Major pathways included hydroxylation, oxidation, and dealkylation, producing 10 transformation products. Catalyst activity followed N,F-doped-TiO2/V2O5 > N-TiO2/V2O5 > TiO2/V2O5. This system efficiently removes TBEP from water, providing a practical solution for environmental remediation.

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